Journal: Journal of Traditional and Complementary Medicine
Article Title: Evaluating the antiviral efficacy and specificity of chlorogenic acid and related herbal extracts against SARS-CoV-2 variants via spike protein binding intervention
doi: 10.1016/j.jtcme.2024.11.009
Figure Lengend Snippet: Effects of chlorogenic acid (3-CQA) on VOC spike proteins binding to hACE2 protein. (A) Chemical structure of 3-CQA. (B) Effects of 3-CQA on the previous VOC spike proteins (from α to γ) binding to hACE2. (C) Effects of 3-CQA on the current VOC spike proteins (from δ to O) binding to hACE2. Data are presented as the mean ± SEM (n = 3). ∗P < 0.05, ∗∗P < 0.01, and ∗∗∗P < 0.001 compared with positive control.
Article Snippet: 1 mg/L of chlorogenic acid standard (ChromaDex Inc.) in MeOH was prepared and diluted into a concentration gradient (0.8–100 mg/L) for plotting the standard curve.
Techniques: Binding Assay, Positive Control